Alzheimer's Disease


(Causes and the way to stop Alzheimer’s)  

Alzheimers Disease
What is Alzheimer's

We don't know the precise explanation for Alzheimer’s. Yet, we all know quite a bit about the way to prevent it.  


“Memory loss may be a leading symptom that emerges at the onset of the disease. At first, past memories remain intact and tiny memory lapses occur. Then mental abilities gradually disappear”. 

Alzheimer's Disease: As human anticipation has grown longer, it's led to the emergence of diseases that were once quite rare. one of these Alzheimer's. At the start, Alzheimer's manifests as a decrease in overall everyday activity. It becomes more apparent as mental functions decrease and cognition weakens. In advanced stages, it results in senility, a tragic condition induced by the deterioration of neurons 


Memory loss may be a leading symptom that emerges at the onset of the disease. At first, past memories remain intact, and tiny memory lapses occur. Then mental abilities gradually disappear. Speaking and hand gestures, which are primarily controlled by the frontal lobes and temporal lobes of the brain, start to fail, amid problems with recognition.  


Although the underlying pathological processes within the brain tissues aren't completely identified, it's known that there are disconnections between the visceral brain and therefore the frontal and temporal lobes. The intensive deterioration of the side cortical regions (the temporoparietal cortex) becomes visible within the amyloid plaques and therefore the coiling nerve fibers as neurons degenerate and advance toward death. 

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Early Sign of Alzheimer's: -  


Early Sign of Alzheimers
Sign of Alzheimer's


Symptoms of Alzheimer’s: -  

  • Memory Loss  
  • Confusion with time or place  
  • Solving Problems  
  • Speaking or Writing Problems  
  • The trouble with Familiar Task  
  • Change in Moods and Personality
  • Making Judgment and Decision  
  • Change in Personality and Behavior




Causes of Alzheimer’s Disease:  

The exact explanation for the disease isn't known. it's in 2-4% of individuals over 65, and this rises to of individuals over 85, indicating the connection of the disease with advanced age. 1-5% of the cases are known to arise from genetic factors. 

A dominant mutation was identified in three different genes during a few cases diagnosed within the early stages of the disease. A gene called APOE was identified to be oversensitive in patients diagnosed with the more common sort of Alzheimer's at later ages.  

One of the hypothesized causes is prions, proteins 100 times smaller than viruses that became known because of mad cow disease. Neither an epidemic nor a bacterium, prions are pathogens formed by the mutation of normal proteins produced in neural cells. Prions are often contagious. it's believed that prions can pass from person to person during a transfusion or dental treatment through unsterilized tools.  

Dementia could be one disorder for the layperson, but in medicine, it refers to many disorders with different underlying causes. Alzheimer's dementia is one of the neurodegenerative diseases during which neurons are destroyed.

Demographic studies have identified several factors that increase the danger of Alzheimer's disease. The energy source of neurons is often disrupted due to a decrease in blood flow into the brain resulting from circulatory damage, especially in patients who have a high vital sign and are overweight.  

The disease, which gradually destroys the neurons and therefore the brain, severs the connections between cells. A typical symptom of the loss of neurons in Alzheimer's begins with the loss of the sense of smell. The death of the cells spreads slowly to regions related to memory than to the whole brain surface. One-fifth of brain mass could be lost as a result.  

The olfactory (smell) center and therefore the bottom a part of the brain are affected at an earlier stage. The Meynert basal nucleus within the central systema nervosum produces a substance (neurotransmitter) required for communication between neurons. 

The presence of this substance is vital for retrieving memories from the archives —that's for remembering. a clear decrease in acetylcholine levels prevents the processing of data, and since STM is negatively affected, it's going to become very hard to recollect events that have only recently happened.  

As losses increase, the acetylcholine produced within the basal nucleus decreases. an interesting finding of Alzheimer's is that the protein buildup in neurons and gaps in certain regions of the brain. 

Some doctors believe that this protein buildup causes the disease, while others argue that it's the body's response to the disease. The result's the same: protein plaques act as a poison that damages the metabolism of neurons, and therefore the patient’s cognitive performance decreases because neurons cannot communicate with one another. 

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Alzheimer's Disease Treatment: - 

Increasing risk for relatives and genetics

Kinship seems to be an important risk factor for almost a third of Alzheimer's patients. The probability that an Alzheimer's patient's siblings and children have the disease is four times higher than for other people. The genes that indicate genetic factors have been identified in some families. 

Among factors that increase the risk of Alzheimer's are nicotine, alcohol, obesity, high cholesterol levels, diabetes, thyroid function disorders (hyperthyroid), frequent concussions, unhealthy diet, heart attack, and paralysis. It is also interesting that depression, anxiety, and increased nervousness may develop at the onset of the disease. 

Alzheimer's and loneliness  

In Alzheimer's as well as other types of dementia, dementia is found to be triggered by a lack of mental activity, which is in part connected to loneliness and isolation from people. In fact, loneliness is considered to be a preliminary symptom of Alzheimer's. 

A study performed with 79 older people (43 female and 36 male) who had symptoms of dementia found that the amount of amyloid plaque was seven times higher in the brains of the participants with a greater decline in mental abilities. Besides, these patients suffered from severe cases of loneliness. 

Is poor sleep a risk factor? 

Observations in sleep laboratories indicate that prolonged periods of poor sleep increase the risk of Alzheimer's. Even a single restless night without deep sleep can increase the beta-amyloid concentration, or Alzheimer's protein, in the brain fluid. In the case of several subsequent nights of restless nights, an increase is observed in the levels of tau protein, a second protein associated with the illness. 

The findings obtained by a team of specialists led by David M. Holtzman from Washington University Department of Medicine show that sleep disorders that are untreated for a long time increase the risk of Alzheimer’s. 

The brain may not be cleaned sufficiently without deep sleep, hence the increase in the levels of protein particles. Yet it has been found that the amounts of beta-amyloid return to normal after a few days of sound sleep. The risk increases after a prolonged lack of deep sleep. It is thus believed that the risk of Alzheimer's increases in people with sleep apnea who wake up repeatedly during the night because of problems breathing. 

Yet it is not clear whether the increase in the amounts of tau and beta-amyloid proteins is related to the onset of the disease and how the findings should be interpreted. The reason for the confusion is that the two proteins also change shape and cause buildups in healthy people, not just in patients. It is therefore not known whether the risk of Alzheimer's can be lowered with a night of sound sleep. 

We can say that warning signs can be found in sleep. Neuroscientists at the University of Toronto have discovered one of the early signs of sleep behavior. They have found that people who beat or kick themselves in their dreams are 80-90% more likely to develop a neurodegenerative disorder such as Parkinson's and dementia at a later age, and this condition, also known as a sleep disorder, could be early signs of a brain disorder that may emerge within fifteen years. 

Another study by Boston University researchers has revealed a correlation between REM sleep (Rapid eye movement sleep) and Alzheimer's. The researchers have found that a reduction in REM or dream-sleep phase increased the risk of disease. On the other hand, not every nightmare is a symptom of the disease. The predictive factor is the desire to move taking place during REM sleep. 

The more efficient the sleep, the less the amyloid plaques 

How long we sleep at night might predict how well our memory will work when we get older. According to Dr. Yo-Elju, sleep disorders seem to contribute to the formation of amyloid plaques. A two-week study was conducted at the Faculty of Medicine at Washington University. Researchers used sleep behavior surveys and machine measurements. 

A quarter of the participants had signs of amyloid plaques. The participants spent eight hours a night in bed. They were disturbed by being woken at different intervals. It was seen in the end that those who were woken more often had greater amyloid plaques. Interestingly, those who slept more than 6.5 hours had the same condition. 

The correlation between poor sleep and amyloid plaques is striking, yet the findings in this study do not provide evidence for a cause-effect relationship. Therefore, longitudinal studies are needed to find out whether sleep disorders contribute to the formation of plaques in the brain. To sum up, these studies indicate that the quality of sleep matters more than the length of sleep. 

It seems more important to have a shorter sleep with a complete REM phase than a ten-hour sleep without REM sleep. 


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Important advice: -

Families need to take care of their elderly in their old age. It is worth noting that the weakness of mental faculties in old age is followed by advice to give in charity and reminding of His favors including spouses, children, and good, healthy sustenance. 

This allusion to the family as a favor makes much sense thinking of the huge difference in the quality of life and health the elderlies have depending on the company of children and grandchildren and the lack thereof.  

“Observations in sleep laboratories indicate that prolonged periods of poor sleep increase the risk of Alzheimer's. Even a single restless night without deep sleep can increase the beta-amyloid concentration, or Alzheimer's protein, in the brain fluid” 


That's all...

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  1. what a wonderful knowledge you have provided regarding this disease.
    I really enjoyed while reading this article.
    Keep posting such type of articles.


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