Hemoglobin

What is Hemoglobin

(A miraculous molecule) 

Hemoglobin


Do you know what hemoglobin does? You should, because it has been perfectly created to keep you alive! 


Hemoglobin is one of the miraculous molecules within the physical body. While its most important function is to carry oxygen in the blood, it also plays a role in maintaining the body's acid-base balance. It also carries carbon monoxide in blood though a much lesser amount than oxygen


Hemoglobin is not yet free to roam in the blood; it is carried in red blood cells, which act as hemoglobin sacs. Red blood cells have almost no other function but to carry hemoglobin. They lose all their organelles, including the nucleus, to be able to carry more hemoglobin and hence, our oxygen. 


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How to Increase Hemoglobin (Hemoglobin Produced): 


Hemoglobin is produced in the bone marrow combining the “hem” molecule with the “globin” molecule. The hem part is produced in the mitochondria of the red blood cell. Two succinyls coenzyme “A” s and two glycine amino acids are combined to form pyrrole


Pyrroles are combined to form uroporphyrin, which is combined with the iron atom to produce the hem. Four hems are combined with four globins, a kind of protein, to produce one hemoglobin molecule. 


Since each hemisphere has one iron atom, all hemoglobin has four atoms of iron. And since an oxygen molecule binds with each other atom, every hemoglobin can carry a total four oxygen molecule-or eight oxygen atoms. The makeup along with its production steps is very complicated and it features a precise and intricate design. 






Hemoglobin Function: 


The blood circulates between the lungs and tissues thanks to continuous work for the heart. As hemoglobin moves through the lungs it binds with oxygen and it follows through tissues is releases the oxygen. 


For this process to work, the bond between oxygen and hemoglobin can be neither too strong not too weak. If it were too strong, oxygen would not be able to break free in the tissues, and the tissues would go without oxygen. If they born where too week, hemoglobin would not be able to bind with enough oxygen in the lungs, in which case the tissues would again not get oxygen. 


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Types of Hemoglobin: 


There are basically two kinds of hemoglobin. The first type is found in fetuses, and it is called fetal hemoglobin (Hb-F). The other is found in adult humans and is called adult hemoglobin (Hb-A). Before being born, the fetus gets oxygen from the mothers warm. 


To get more oxygen from the mother, fetal Hemoglobin is designed to bind more strongly with oxygen. One is tempted to ask: Because fatal hemoglobin binds so strongly with oxygen, will they fetus tissue not be deprived of oxygen? 


Yet there is no need to worry. Because there is less oxygen in fetuses than an adult human, this different hemoglobin easily breaks free from the oxygen in the low oxygen environment. After the baby is born, the body produces Hb-A instead of Hb-F because it starts to breathe through its own lungs. 






Hemoglobin Structure:



what is hemoglobin
(credit by-commons.wikimedia.org)




How Hemoglobin work: 


Hemoglobin is charged with carrying 97% of the oxygen carried in the blood. 3% of the oxygen is carried in dissolved form in plasma. Because an increase in dissolved oxygen leads to oxygen poisoning, it is not desirable at all. If one breathes from a tube containing 100% oxygen instead of atmospheric air containing 80% nitrogen, the amount of dissolved oxygen in the blood increases, causing oxygen poisoning.  


Hemoglobin is designed to store some oxygen, too. At rest, there is 20ml of oxygen in the hemoglobin of 100ml of arterial blood, only 5 milliliters of the oxygen will be given to cells. The remaining 15 ml remains in the hemoglobin. In other words, not all oxygen in the hemoglobin is transferred to the body’s tissues. 


This is a security measure against possible risks. In the event that blood does not come from the lungs, this stored oxygen is used so that life can continue, though for a short time. The same situation is experienced when we do not breathe for a long time. 





Exercise 


During exercise or work that requires physical effort, the amount of oxygen demanded by the body increased twenty-fold. The heart works faster as does the circulatory system. Hemoglobin is supposed to get 20 times more oxygen from the lungs so that it can take 20 times more oxygen to the cells. 


Body temperature increases, too. Hemoglobin is designed to respond to all these changes. During exercise, hemoglobin starts to give almost all the oxygen to the tissues. When it gets back to its lungs, it is like an empty truck can load more oxygen.  


The exercise in person breathes more deeply and quickly; thus, the lungs work faster, the heart pumps blood with greater force and speed, and the design of the hemoglobin is just good enough to carry more oxygen to the tissues. 





Inflammatory Diseases 


Cellular metabolism speeds up when a person has an inflammatory disease. More oxygen is needed because the chemical reaction in cells gain is speed. The body's temperature increases; so, too, the number of acids and carbon dioxide in the blood due to an increase in metabolic rate. In addition, the amount of very important molecules in the blood increases. 


This molecule is called diphosphoglycerate. It is charged with protecting the cell during inflammatory disease and preventing cell death. Diphosphoglycerate hemoglobin to send more oxygen to the body tissue. As we can see, the body has been perfectly created to ensure it receives enough oxygen, even during illnesses. 





Transfer of Carbon dioxide 


Hemoglobin is also assigned the task of carrying carbon dioxide. Carrying carbon dioxide in the blood is easier than carrying oxygen, as carbon dioxide is twenty times more water-soluble than oxygen. Doctors, therefore, do not have to make an extra effort to reduce the amount of carbon dioxide in the blood, and it is enough to give oxygen to patients with breathing problems. If carbon dioxide were not easy to dispose of, we would face an enormous problem, because there is no way to disposing of carbon dioxide and it is virtually impossible to develop one. 


A vast amount of carbon dioxide in the blood (70%) is carried in the form of bicarbonate. First, carbon dioxide combines with water, as a result of which carbonic acid, and then bicarbonate, are produced. After these reactions, carbon dioxide hides in bicarbonate and arrives at the lungs. Then bicarbonate combines with H+, by which carbonic acid is made. Then water and carbon dioxide are produced. 


The carbon dioxide that breaks up from the bicarbonate is discharged through the lungs into the atmosphere. 7% of the dissolved carbon dioxide in the blood is carried in plasma and 23% in the hemoglobin. That is to say, as hemoglobin travels from the lungs to the cells, it carries oxygen, and it is returns from the cell it loads off some of the carbon dioxide. 




Acid-base balance 


The pH value of human blood is 7.4, on average. It is vital for cells that the pH of the blood remains stable. The regulation of the acid (H+) ion concentration in the body fluids is called the acid-base balance. Little changes in H+ plus ions cause an enormous change in circular chemical reactions. 


The regulation of the balance of H+ plus ions is therefore crucial for the body's internal balance. 


Hemoglobin plays an important role in the acid-base balance of the blood. If a strong acid finds their way into the bloodstream because of a certain disease, hemoglobin help prevent as an increase in the amount of acid by binding with the acid or carbon dioxide. A similar role is also true for times when the number of base rises.  


When we study hemoglobin and the chemical substances and reaction it is involved in, we can see that they are all arranged extremely precisely, and everything is in its proper place.  


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Conclusion:


The blood circulates between the lungs and tissues thanks to the continuous work of the heart. As hemoglobin moves through the lungs it binds with oxygen and as it flows through tissue it releases the oxygen. 


If strong acids find their way into the bloodstream because of certain diseases, hemoglobin help prevent an increase in the amount of acid (and decrease in pH) by binding with the acid or carbon dioxide. 




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  1. Nice work. Really we should be concerned about our health in this restless life.

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